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INTEGRATED SOLUTIONS FOR FISH

Automation solution for scanning and analysis of tissue-based FISH slides

Pathology
digital

Integrated solutions
 for FISH

Solutions
for pathology

Pathology
Molecular

Solutions
for Cytogenetics

Analysis
of nano particles

PRODUCTS for fish

slide preparation, digitization and analysis

EasyFish®

EasyFish® complements Excilone’s comprehensive Fish solution, which already includes Cytotest® probes, the CytoHyb500 denaturation-hybridization system and PathScan® scanners. Efficiency, openness, practicality and user protection.

EasyFish® is a device that enables complete automation of the Fish slide pretreatment process.
(tissue sections) with :

Efficiency and openingspan
• Total automation of the process (dewaxing, rehydration, permeabilization, enzymatic digestion, dehydration) with intermediate washes
• Extemporaneous enzyme preparation (automatic dilution from concentrated solution)
• Heating the slides at the start of the protocol
• Protocol standardization
• Suitable for all probes, regardless of supplier

Practicality
• Ready-to-use reagents (except enzyme)
• Ready-to-use enzyme dilution buffer for automatic extemporaneous preparation
• Management of 1 to 20 slides per run, with adaptation of the reagent volume used
• Management of multiple digestion times in a single run using semi-automatic mode
• Pre-recorded default programs
• Customizable programs
• French-language software interface with touch-screen control panel
• Monitoring of technique progress, with indication of time remaining in the current step and total time.

Operator safety and protection
• Reduce reagent handling by using ready-to-use solutions
• Use of substitutes for the dewaxing step
• “Autoboot” of the appliance on start-up with check of correct operation
• Self-cleaning of all manifolds on ignition and at the end of the process
• Control of reagent volumes drawn from and dispensed into the reaction chamber, with alarm in case of insufficient volume
• Waste volume control with fill alarm
• Presence control of waste, alcohol and distilled water containers with alarm

Dimensions and electrical features
 • Floor-standing machine with adjustable feet and castors.
• Dimensions: 700 x 500 x 1000 mm (W x D x H)
• Weight: 50 kg
• Voltage: 220-240 V
• Power: 1500 W

Reagents not supplied
 • Distilled water (800 to 1000 ml for a cycle of 20 slides)
• Absolute alcohol (300 to 500 ml per cycle of 20 slides)

  Les Sondes de FISH Cytotest

 
Cytotest est une société spécialisée dans la conception et la production de sondes d’hybridation in situ par fluorescence de l’ADN (FISH). La FISH est une technique puissante conçue pour détecter la présence ou l’absence, la localisation, l’intégrité et la quantité de séquences génomiques dans des échantillons de tissus ou de cellules. Introduit au début des années 1980 comme un outil de recherche cytogénétique, la FISH est aujourd’hui la technique la plus importante pour le diagnostic clinique des anomalies chromosomiques.

Depuis sa création, la société a fait progresser ses techniques de production de nucléotides marqués en fluorescence de la conception à la fabrication de sondes FISH. À ce jour, Cytotest a développé et testé avec succès une série très diversifiée de sondes ADN FISH pour des applications de diagnostic moléculaire en oncologie, en médecine personnalisée, en tests prénataux, en cancérologie et dans d’autres domaines.

La gamme Cytotest comprend des sondes pour des cibles à usage clinique ainsi que des cibles à usage de recherche mais aussi des produits conçus sur mesure (Sondes à façon). De nouveaux produits sont ajoutés en permanence, en partie grâce à leurs efforts internes de recherche et de développement, mais le plus souvent à la suite de demandes de développement de tests spécifiques de la part de nos clients, en particulier dans les cancers rares et les diagnostics compagnons.

 

 

 

 

 

 

 

 

 

 

Les produits Cytotest sont préparés à des fins de recherche et de diagnostic aux États-Unis, en Chine et dans le monde entier. Tous les produits sont fabriqués conformément aux réglementations en vigueur et sont soumis à des tests de qualité pour garantir qu’ils répondent aux normes les plus strictes. Un effort d’optimisation régulier a abouti à des produits d’excellence. En parallèle, Cytotest suit attentivement les avancées scientifiques et technologiques, observe les discussions de pointes sur les normes de l’industrie diagnostique, la certification et les exigences réglementaires, et reste attentif aux changements de consensus concernant les diagnostics in vitro et les tests en laboratoire.

Avec une équipe multidisciplinaire de chercheurs passionnés et dévoués, Cytotest peut effectuer des fabrications à toutes les échelles et est en mesure d’offrir des solutions pour un large éventail de besoins de tests de diagnostic, de la production de sonde standard à la conception flexible personnalisée. Les scientifiques de Cytotest ont des collaborations stratégiques pour développer des tests de diagnostic moléculaire pour des pathologies nouvelles et rares, des niches de diagnostic non couvertes et pour la commercialisation dans des régions du monde mal desservies.

La mission de CytoTest Inc. est de transformer les découvertes génomiques humaines en produits utiles, et de concevoir, fabriquer et valider des réactifs de diagnostic génétique et clinique de la plus haute qualité. Leur objectif principal est le développement de solutions de cytogénétique moléculaire à la pointe de la technologie et néanmoins à un prix abordables. Cytotest se consacre à fournir des produits économiquement intéressants, un service clientèle proactif et un support technique fiable.

 

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Hybridizer

The CytoHYB CT500 denaturation and hybridization instrument is a programmable system for automated processing of FISH protocols on samples deposited on glass slides.

The machine offers a number of advantages, including convenient touch-screen programming, an integrated USB port, unrivalled heating speed and precision, minimal temperature variation and a higher humidity range. A unique design with liquid gutters provides convenient humidification and stable humidity control inside the chamber. The instrument is easy to clean, and there’s no need to use disposable foam strips for humidity, or any other consumables to replace.

Accepting a wide range of sample types, the tray is equipped with sliding guides that hold the slides in place and allow one-handed placement and removal. Its use considerably reduces working time without compromising precision and reproducibility.

The product is suitable for a wide variety of experimental denaturation and hybridization strategies, with four distinct modes of operation: denaturation/hybridization, hybridization, customization and PC processes.

R in situ. The integrated hot-water tank and sealed heating cover ensure perfect experimental reproducibility, for processing up to 12 slides simultaneously.

Available for 110-120V or 220-240V power supply.

PathScan® Combi

PathScan® Combi is an automated platform for brightfield slide scanning and analysis on tissue, and for whole-slide Fluorescence scanning in up to 6 colors.

PathScan® Combi is a histological slide scanner that combines transmitted light and fluorescence scanning thanks to a dual-camera system (color and monochrome):

  • Oil immersion scanning of tissue FISH slides
  • Whole slide immunofluorescence scanning (up to 5 colors)
  • Brightfield scanning, including immersion (high-resolution)

PathScan® Combi enables brightfield and fluorescence images to be matched for FISH analysis using EVA® software, in the same tumor zone as that previously identified by the pathologist in brightfield.

With its dedicated Web application, PathScan® Combi provides remote access to acquired images and password-protected access to individual files and working environments.

Specifications :

  • Available lenses: 2x, 4x, 10x 20x, 40x, 60x immersion (upgradeable configuration).
  • Capacity: 8 blades
  • Number of lenses : Up to 7
  • Resolution at x20: 0.5 micron/pixel, 0.25 µm/pxl at x40, 0.107 µm/pxl at x60 (immersion)
  • Image compression: JPEG-2000
  • Bar code reader: Yes
  • Filters: DAPI, FITC, TRITC (scalable configuration)
  • Filters: up to 5 positions (upgradeable configuration)
  • Backlight illumination: LED
  • Illumination Fluorescence: Metal-halide
  • Display: 24 » LCD screen (1920X1200)

The scanner complies with the In Vitro Diagnostic Regulation (IVDR) (EU) 2017/746.

Excilone® View Web

Excilone® View Web is a powerful web-based platform for managing, viewing and sharing virtual slides from Excilone PathScan® Combi and PathScan® Touch slide scanners, as well as from the market’s leading slide scanners.

Allows you to centralize all your virtual blades in the same environment, regardless of image format.

Excilone® View Web can be installed on physical servers or in the cloud, and an SSL certificate with Https protocol ensures a secure connection and data protection.

The Excilone® View Web license is perpetual with no limit on the number of users.

Excilone® View Web is available in English and French. The platform is accessible from PCs, Macs and tablets. And it’s browser-compatible.

Excilone® View Web allows you to perform the following operations:

  • Access virtual blades from your web browser, without installing any software, and from anywhere.
  • Navigate any type of virtual slide: brightfield, fluorescence and any format.
  • View multiple slides simultaneously.
  • Synchronize blade display.
  • Manage blades within studies according to your different projects.
  • Give your collaborators or partners access to your studies by managing their access rights (management, annotation or consultation rights).
  • Invite other users to join you in meeting mode for a virtual multi-headed slide show.
  • Annotate and measure virtual slides.

Key words :

  • Blade visualization with simple web access.
  • Access with a password-protected user ID.
  • Manage users and their associated rights within studies.
  • Image management by study and sub-study.
  • Link documents to your studies.
  • Share your studies by inviting other users.
  • Maintain traceability with the audit function.
  • View slides in brightfield and fluorescence.
  • Multi-channel display and Z-stack navigation.
  • Compatible with almost all image formats.
  • Synchronized serial blade navigation.
  • Annotations and measurements (import/export).
  • Meeting mode for virtual multi-head playback.
  • Collaborative solution for teaching and research.
  • Perpetual license and unlimited number of users.
  • Numerous virtual blade formats.
  • Local and Cloud servers.

Compatible image formats :

  • Leica® (TIF, SVS, AFI)
  • PathScan® (TIF, GXP)
  • PathScan® Touch (TIF, SVS)
  • Hamamatsu® (NDPI, NDPIS)
  • Huron® (TIF)
  • 3DHistech® (MRXS)
  • Olympus® (VSI)
  • Zeiss (CZI)

Excilone® View Analyse

Excilone® View Analyse (EVA®) is digital pathology software for viewing images from Excilone PathScan® slide scanners and other leading slide scanners.

EVA® offers advanced features for intuitive navigation of all your slides (brightfield, fluorescence).

With Excilone® View Analyse you can also :

  • View several virtual slides simultaneously
  • Annotate slides and share images
  • PathScan® FISH slide analysis


The benefits:

  • Independent analysis of probe suppliers ;
  • Core segmentation using artificial intelligence ;
  • Core gallery for easy interpretation ;
  • Dynamic link between image and core gallery results ;
  • Tools to facilitate review and correction of results (addition, deletion of cores).

For research only

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